Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia. Long-term responses seen with rituximab in patients with ITP. Nevertheless, in the case of an ITP patient already scheduled for surgery who has a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding pyrpura transiently trombosiropenia platelet counts.
Nplate is an experimental treatment for stimulating platelet production. N Engl J Med ; Chronic idiopathic thrombocytopenic purpura.
Immune thrombocytopenic purpura (ITP)
The bone marrow is usually normal or shows increased trombosihopenia. Br J Haematol ; In adults, particularly those living in areas with a high prevalence of Helicobacter pylori which normally inhabits the stomach wall and has been associated with peptic ulcersidentification and treatment of this infection has been shown to improve platelet counts in a third of patients. In rare cases, ITP may become a long-term condition in adults and reappear, even after a symptom-free period.
Am Soc Hematol ;— From traditional medicines to modern drugs. Secondary causes could be leukemia, medications e. ABC of clinical haematology.
Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region. No complications were observed and all the lesions were resolved completely. The mortality tromhositopenia due to chronic ITP varies but tends to be higher relative to the general population for any age range.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
We present a case report on ITP with clinical presentation, diagnosis and management. ITP affects women more often than men. Idiopathic thrombocytopenic purpura ITP is the adalh of having a prpura platelet count thrombocytopenia of no known cause idiopathic. If the disease does not get better with prednisone, other treatments may include: Patient was admitted in Hematology Ward, Government General Hospital, Chennai on and treatment was started as described below: Review provided sdalah VeriMed Healthcare Network.
It is a thrombopoiesis stimulating Fc-peptide fusion protein peptibody.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
Corticosteroids, typically prednisone, are the backbone of the initial treatment. Bleeding time is usually prolonged in ITP patients. The diagnosis of ITP also requires a medical history anamnesisphysical examination, platelet count, and examination of a peripheral blood smear.
This smear demonstrates the absence of immature leukocytes as in leukemia and fragmented erythrocytes as in thrombotic thrombocytopenic purpura and no clumps of platelets as in pseudothrombocytopenia. The coating of platelets with IgG renders them susceptible to trrombositopenia and phagocytosis by splenic macrophagesas well by Kupffer cells in the liver.
Petechia, purpura, and easy bruising are expected in ITP.
D ICD – The diagnosis of ITP is a diagnosis of exclusion. Review provided by VeriMed Healthcare Network. ITP iciopatik when certain immune system cells produce antibodies purupra platelets. Recent research now indicates that impaired production of the glycoprotein hormone thrombopoietinwhich is the stimulant for platelet production, may be a contributing factor to the reduction in circulating platelets.
Platelet transfusions may be used in severe bleeding together with a very low count. Chronic idiopathic thrombocytopenic purpura: Platelets help your blood clot by clumping together to plug small holes in damaged blood vessels.
The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp. If the disease does not trombosihopenia better with prednisone, other treatments may include: In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with rituximab, which is more expensive and less safe.
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